Regulation of mitochondrial gene expression, the epigenetic enigma.

@article{Mposhi2017RegulationOM,
  title={Regulation of mitochondrial gene expression, the epigenetic enigma.},
  author={Archibold Mposhi and Monique G. P. van der Wijst and Klaas Nico Faber and Marianne G Rots},
  journal={Frontiers in bioscience},
  year={2017},
  volume={22},
  pages={
          1099-1113
        }
}
Epigenetics provides an important layer of information on top of the DNA sequence and is essential for establishing gene expression profiles. Extensive studies have shown that nuclear DNA methylation and histone modifications influence nuclear gene expression. However, it remains unclear whether mitochondrial DNA (mtDNA) undergoes similar epigenetic changes to regulate mitochondrial gene expression. Recently, it has been shown that mtDNA is differentially methylated in various diseases such as… 

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