Regulation of mitochondrial biogenesis during myogenesis

  title={Regulation of mitochondrial biogenesis during myogenesis},
  author={Alexander H V Remels and Ramon C. J. Langen and Patrick Schrauwen and Gert Schaart and Harry R Gosker},
  journal={Molecular and Cellular Endocrinology},
Pathways involved in mitochondrial biogenesis associated with myogenic differentiation are poorly defined. Therefore, C(2)C(12) myoblasts were differentiated into multi-nucleated myotubes and parameters/regulators of mitochondrial biogenesis were investigated. Mitochondrial respiration, citrate synthase- and beta-hydroxyacyl-CoA dehydrogenase activity as well as protein content of complexes I, II, III and V of the mitochondrial respiratory chain increased 4-8-fold during differentiation… CONTINUE READING


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