Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization.

@article{Popovic2009RegulationOM,
  title={Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization.},
  author={Relja Popovic and Laurie E Riesbeck and Chinavenmeni S. Velu and Aditya Chaubey and Jiwang Zhang and Nicholas J. Achille and Frank E Erfurth and Katherine Eaton and Jun Lu and H. Leighton Grimes and Jianjun Chen and Janet D. Rowley and Nancy J. Zeleznik-Le},
  journal={Blood},
  year={2009},
  volume={113 14},
  pages={3314-22}
}
Chromosomal translocations involving the Mixed Lineage Leukemia (MLL) gene produce chimeric proteins that cause abnormal expression of a subset of HOX genes and leukemia development. Here, we show that MLL normally regulates expression of mir-196b, a hematopoietic microRNA located within the HoxA cluster, in a pattern similar to that of the surrounding 5' Hox genes, Hoxa9 and Hoxa10, during embryonic stem (ES) cell differentiation. Within the hematopoietic lineage, mir-196b is most abundant in… CONTINUE READING