Regulation of microtubule severing by katanin subunits during neuronal development.

@article{Yu2005RegulationOM,
  title={Regulation of microtubule severing by katanin subunits during neuronal development.},
  author={Wenqian Yu and Joanna M. Solowska and Liang Sheng Qiang and Arzu Karabay and Douglas H. Baird and Peter W. Baas},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 23},
  pages={5573-83}
}
Katanin, the microtubule-severing protein, consists of a subunit termed P60 that breaks the lattice of the microtubule and another subunit termed P80, the functions of which are not well understood. Data presented here show that the ratio of P60 to P80 varies markedly in different tissues, at different phases of development, and regionally within the neuron. P80 is more concentrated in the cell body and less variable during development, whereas P60 often shows concentrations in the distal tips… CONTINUE READING

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