Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP.

@article{AlBassam2011RegulationOM,
  title={Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP.},
  author={Jawdat Al-Bassam and Fred Chang},
  journal={Trends in cell biology},
  year={2011},
  volume={21 10},
  pages={604-14}
}
The molecular mechanisms by which microtubule-associated proteins (MAPs) regulate the dynamic properties of microtubules (MTs) are still poorly understood. We review recent advances in our understanding of two conserved families of MAPs, the XMAP215/Dis1 and CLASP family of proteins. In vivo and in vitro studies show that XMAP215 proteins act as microtubule polymerases at MT plus ends to accelerate MT assembly, and CLASP proteins promote MT rescue and suppress MT catastrophe events. These are… CONTINUE READING

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