Regulation of microtubule dynamic instability in vitro by differentially phosphorylated stathmin.

@article{Manna2009RegulationOM,
  title={Regulation of microtubule dynamic instability in vitro by differentially phosphorylated stathmin.},
  author={Tapas Manna and Douglas A Thrower and Srinivas Honnappa and Michel O. Steinmetz and Leslie Wilson},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 23},
  pages={15640-9}
}
Stathmin is an important regulator of microtubule polymerization and dynamics. When unphosphorylated it destabilizes microtubules in two ways, by reducing the microtubule polymer mass through sequestration of soluble tubulin into an assembly-incompetent T2S complex (two alpha:beta tubulin dimers per molecule of stathmin), and by increasing the switching frequency (catastrophe frequency) from growth to shortening at plus and minus ends by binding directly to the microtubules. Phosphorylation of… CONTINUE READING