Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9.

@article{Xu2000RegulationOM,
  title={Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9.},
  author={Wenbing Xu and Lili Gong and Maher M Haddad and Oliver Bischof and Judith Campisi and Edward T. H. Yeh and Estela E. Medrano},
  journal={Experimental cell research},
  year={2000},
  volume={255 2},
  pages={135-43}
}
The basic helix-loop-helix/leucine zipper (bHLH/ZIP) microphthalmia-associated transcription factor (MITF) regulates transcription of genes encoding enzymes essential for melanin biosynthesis in melanocytes and retinal pigmented epithelial cells. To determine how MITF activity is regulated, we used the yeast two-hybrid system to identify proteins expressed by human melanoma cells that interact with MITF. The majority of clones that showed positive interaction with a 158-amino-acid region of… CONTINUE READING

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