Regulation of microglial proliferation during chronic neurodegeneration.

@article{GmezNicola2013RegulationOM,
  title={Regulation of microglial proliferation during chronic neurodegeneration.},
  author={Diego G{\'o}mez-Nicola and Nina L Fransen and Stefano Suzzi and V Hugh Perry},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 6},
  pages={
          2481-93
        }
}
An important component of chronic neurodegenerative diseases is the generation of an innate inflammatory response within the CNS. Microglial and astroglial cells play a key role in the development and maintenance of this inflammatory response, showing enhanced proliferation and activation. We studied the time course and regulation of microglial proliferation, using a mouse model of prion disease. Our results show that the proliferation of resident microglial cells accounts for the expansion of… CONTINUE READING

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