Regulation of microglia by CD4+ and CD8+ T cells: selective analysis in CD45-congenic normal and Toxoplasma gondii-infected bone marrow chimeras.

@article{Schlueter2001RegulationOM,
  title={Regulation of microglia by CD4+ and CD8+ T cells: selective analysis in CD45-congenic normal and Toxoplasma gondii-infected bone marrow chimeras.},
  author={Dirk Schlueter and Tobias Meyer and Andreas Strack and S. Reiter and Marianne Kretschmar and Otmar Dieter Wiestler and Herbert Hof and Martina Deckert},
  journal={Brain pathology},
  year={2001},
  volume={11 1},
  pages={44-55}
}
Microglia, the resident macrophage population of the central nervous system, is rapidly activated in murine Toxoplasma encephalitis (TE). However, the precise contribution of microglia to intracerebral immune reactions and the in vivo regulation of microglial activity are still poorly understood. To selectively analyse microglial reactions in TE, we have established a model of radiation-induced CD45-congenic bone marrow chimeras between CD45.2+ C57BL/6 (recipient) and CD45.1+ B6.SJL (donor… CONTINUE READING
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