Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1.

@article{Adam2000RegulationOM,
  title={Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1.},
  author={Liana Adam and Ratna K Vadlamudi and Mahitosh Mandal and Jonathan Chernoff and Rakesh Kumar},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 16},
  pages={12041-50}
}
Stimulation of growth factor signaling has been implicated in the development of invasive phenotype and p21-activated kinase (PAK1) activation in human breast epithelial cancer cells. To further explore the roles of PAK1 in the invasive behavior of breast cancer cells, in the present study we investigated the influence of inhibition of PAK1 activity on the reorganization of cytoskeleton components that control motility and invasiveness of cells, using a highly invasive breast cancer MDA-MB435… CONTINUE READING
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PAK1 Regulation of Invasion 12050 by gest on A uust 31

  • S. Bagrodia, B. Derijard, R. J. Davis, R. A. Cerione
  • J. Biol. Chem. 270,
  • 1995
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