Regulation of methionine synthesis in Salmonella typhimurium: mutants resistant to inhibition by analogues of methionine.

@article{Lawrence1968RegulationOM,
  title={Regulation of methionine synthesis in Salmonella typhimurium: mutants resistant to inhibition by analogues of methionine.},
  author={Daniel A Lawrence and Debbie A. Smith and Robin J Rowbury},
  journal={Genetics},
  year={1968},
  volume={58 4},
  pages={473-92}
}
BIOCHEMICAL and genetical experiments with methionine auxothrophs of Salmonella typhimurium (SMITH 1961 ; SMITH and CHILDS 1966; CHILDS and SMITH unpublished) have resulted in the recognition of six structural genes ( m t A , B, C, E, F and H ) concerned with well defined sequential steps in the biosynthesis of methionine (Figure 1) . Mutants of another gene (metG) do not have a specific enzyme deficiency: they are leaky due to a low level of activity of all the methimine enzymes. Methionine… CONTINUE READING

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