Regulation of metallothionein genes by the ACE1 and AMT1 transcription factors.

@article{Thorvaldsen1993RegulationOM,
  title={Regulation of metallothionein genes by the ACE1 and AMT1 transcription factors.},
  author={Joanne L. Thorvaldsen and Andrew K. Sewell and C L McCowen and Dennis R Winge},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 17},
  pages={
          12512-8
        }
}
The AMT1 metalloregulatory trans-acting factor from Candida glabrata was found to functionally mimic the ACE1 metalloregulatory trans-acting factor from Saccharomyces cerevisiae in the copper-induced expression of the chromosomal S. cerevisiae metallothionein gene. Plasmid constructs with promoters of various metal-inducible genes fused to the bacterial beta-galactosidase (lacZ) reporter gene were used in S. cerevisiae to evaluate the roles of ACE1 and AMT1 in mediating metal-stimulated… CONTINUE READING

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