Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins.

  title={Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins.},
  author={L. Hicke and R. Dunn},
  journal={Annual review of cell and developmental biology},
  • L. Hicke, R. Dunn
  • Published 2003
  • Biology, Medicine
  • Annual review of cell and developmental biology
  • Ubiquitin regulates protein transport between membrane compartments by serving as a sorting signal on protein cargo and by controlling the activity of trafficking machinery. Monoubiquitin attached to integral plasma membrane proteins or to associated transport modifiers serves as a regulated signal for internalization into the endocytic pathway. Similarly, monoubiquitin attached to biosynthetic and endocytic membrane proteins is a signal for sorting of cargo into vesicles that bud into the late… CONTINUE READING
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