Regulation of melanogenesis--controversies and new concepts.

  title={Regulation of melanogenesis--controversies and new concepts.},
  author={Karin Uta Schallreuter and Sonal Kothari and Bhaven Chavan and Jennifer D Spencer},
  journal={Experimental dermatology},
  volume={17 5},
Despite many efforts, regulation of skin and hair pigmentation is still not fully understood. This article focuses mainly on controversial aspects in pigment cell biology which have emerged over the last decade. The central role of tyrosinase as the key enzyme in initiation of melanogenesis has been closely associated with the 6BH4 dependent phenylalanine hydroxylase (PAH) and tyrosine hydroxylase isoform I (THI) providing evidence for an old concept of the three enzyme theory in the initiation… CONTINUE READING
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