Corpus ID: 2660037

Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid.

@article{Hosoi1985RegulationOM,
  title={Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid.},
  author={Junichi Hosoi and Etsuko Abe and Tatsuo Suda and Toshio Kuroki},
  journal={Cancer research},
  year={1985},
  volume={45 4},
  pages={
          1474-8
        }
}
Melanin synthesis of B16 mouse melanoma cells was found to be stimulated dose and time dependently by 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3], the hormonal form of vitamin D3. The stimulation of melanogenesis resulted from an increase in the activity of tyrosinase, a key enzyme in melanin synthesis. The minimum dose required for this stimulation was as low as 0.05 ng/ml, or 0.12 nM, a physiological level of plasma 1 alpha,25(OH)2D3. The stimulation by 1 alpha,25(OH)2D3 was specific… Expand
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273 Citations
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273 Citations

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Human Melanocytes as a Target Tissue for Hormones: In Vitro Studies with 1α-25, dihydroxyvitamin D3, α-melanocyte Stimulating Hormone, and Beta-estradiol
TLDR
The results indicate that melanocytes from normal human foreskin in culture have the capacity to respond directly to several hormones, and suggest that these cells form a useful model to study the effect of various hormones on pigment cell function. Expand
Hormonal effects of vitamin D3 on epidermal melanocytes
TLDR
A major immunoreactive species that migrated in the 53‐kD region in normal melanocytes was observed and was smaller in melanoma cells than innormal melanocytes, predicting a direct role for 1,25(OH)2 D3 as an effector of normal melanocyte function. Expand
Retinoic acid is a potent inhibitor of inducible pigmentation in murine and hamster melanoma cell lines.
TLDR
Trans retinoic acid (RA) appears to be a new and potent tool for understanding mechanisms regulating induction of the pigmentary system in Cloudman mouse melanoma cells. Expand
Regulation of melanogenesis induced by 5-methoxypsoralen without ultraviolet light in murine melanoma cells.
TLDR
In murine melanoma cells 5-MOP stimulates melanogenesis by increasing activity and synthesis of tyrosinase, and the role of cyclic AMP and protein kinase C (PKC) is explored. Expand
In vitro modulation of proliferation and melanization of melanoma cells by citrate
TLDR
The increased melanin synthesis was shown to be due to stimulation of cellular tyrosine hydroxylase activity by citrate, which adds further support to the critical role of intramelanosomal pH in regulation of melanogenesis. Expand
Inhibitory effects of alpha-arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model.
TLDR
Results indicate that alpha-arbutin is an effective and safe ingredient for skin-lightening. Expand
Vitamin D, its precursors, and metabolites do not affect melanization of cultured human melanocytes.
TLDR
The combined data strongly suggest that neither vitamin D3 nor its precursors or metabolites directly mediate melanogenesis in newborn foreskin-derived melanocytes, or its active metabolite 1,25-dihydroxyvitamin D3. Expand
Investigation of the regulation of pigmentation in alpha-melanocyte-stimulating hormone responsive and unresponsive cultured B16 melanoma cells.
TLDR
Evidence is presented for a separate pathway of melanogenesis that is independent of cAMP as calmodulin antagonists, which do not elevate cAMP, increased tyrosinase activity, and melanin production in both 1 degree and F1 cells. Expand
Human melanoma cells: functional modulation by calciotropic hormones.
TLDR
It is indicated that the phenotype of human melanoma cells can be modulated by the calciotropic hormones 1,25(OH)2D3 and calcitonin. Expand
Anti-melanogenesis effect of dehydroglyasperin C through the downregulation of MITF via the reduction of intracellular cAMP and acceleration of ERK activation in B16F1 melanoma cells.
TLDR
DGC could be used as a whitening ingredient in skin and clinical usage against hyperpigmentation, and induced the downregulation of MITF through suppression of cAMP-CREB pathway. Expand
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TLDR
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  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
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TLDR
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