Regulation of megalin expression in cultured proximal tubule cells by angiotensin II type 1A receptor- and insulin-mediated signaling cross talk.

@article{Hosojima2009RegulationOM,
  title={Regulation of megalin expression in cultured proximal tubule cells by angiotensin II type 1A receptor- and insulin-mediated signaling cross talk.},
  author={Michihiro Hosojima and Hiroyoshi Sato and Keiko Yamamoto and Ryohei Kaseda and Taeko Soma and Asako Kobayashi and Akiyo Suzuki and Hideyuki Kabasawa and Aya Takeyama and Kenji Ikuyama and Noriaki Iino and Akira Nishiyama and Thomas J. Thekkumkara and Tetsuro Takeda and Yoshiki Suzuki and Fumitake Gejyo and Akihiko Saito},
  journal={Endocrinology},
  year={2009},
  volume={150 2},
  pages={871-8}
}
Impairment of proximal tubular endocytosis of glomerular-filtered proteins including albumin results in the development of proteinuria/albuminuria in patients with chronic kidney disease. However, the mechanisms regulating the proximal tubular function are largely unknown. This study aimed to investigate the role of angiotensin II type 1A receptor (AT(1A)R)- and insulin-mediated signaling pathways in regulating the expression of megalin, a multiligand endocytic receptor in proximal tubule cells… CONTINUE READING

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