Regulation of megakaryocyte phenotype in human erythroleukemia cells.

  title={Regulation of megakaryocyte phenotype in human erythroleukemia cells.},
  author={Michael William Long and C H Heffner and Jessica L. Williams and Christoph Peters and Edward V. Prochownik},
  journal={The Journal of clinical investigation},
  volume={85 4},
Induction of human erythroleukemia (HEL) cells with nanomolar tumor-promoting phorbol myristate acetate (PMA) diesters results in the synchronous acquisition of multiple markers of the megakaryocyte phenotype. Induced cells markedly increase their content of cytoplasm and show features of morphological maturation. At the ultrastructural level, PMA-treated cells show increases in cytoplasm, nuclear lobulation and nucleolar content, and free ribosomes. Limited numbers of cells also express alpha… CONTINUE READING


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