Regulation of mean and noise of the in vivo kinetics of transcription under the control of the lac/ara-1 promoter.

@article{Kandhavelu2012RegulationOM,
  title={Regulation of mean and noise of the in vivo kinetics of transcription under the control of the lac/ara-1 promoter.},
  author={Meenakshisundaram Kandhavelu and Jason Lloyd-Price and Abhishekh Gupta and Anantha-Barathi Muthukrishnan and Olli Yli-Harja and Andre S. Ribeiro},
  journal={FEBS letters},
  year={2012},
  volume={586 21},
  pages={3870-5}
}
The kinetics of transcription initiation in Escherichia coli depend on the duration of two rate-limiting steps, the closed and the open complex formation. In a lac promoter variant, P(lac/ara-1), the kinetics of these steps is controlled by IPTG and arabinose. From in vivo single-RNA measurements, we find that induction affects the mean and normalized… CONTINUE READING