Regulation of matrix metalloproteinase expression in tumor invasion.

  title={Regulation of matrix metalloproteinase expression in tumor invasion.},
  author={Jukka Westermarck and Veli Matti K{\"a}h{\"a}ri},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={13 8},
Degradation of basement membranes and stromal extracellular matrix (ECM) is crucial for invasion and metastasis of malignant cells. Degradation of ECM is initiated by proteinases secreted by different cell types participating in tumor cell invasion, and increased expression or activity of every known class of proteinases (metallo-, serine-, aspartic-, and… CONTINUE READING