Regulation of mast cell activation through FcepsilonRI.

  title={Regulation of mast cell activation through FcepsilonRI.},
  author={Sho Yamasaki and Takashi K. Saito},
  journal={Chemical immunology and allergy},
The cross-linking of FcepsilonRI on mast cells by IgE and antigen (Ag) initiates activation cascades that lead to allergic responses. FcepsilonRI is composed of an alpha and a Beta monomer, and a gamma homodimer, and the Beta and gamma chains possess immunoreceptor tyrosine-based activation motifs (ITAMs). Through the phosphorylation of ITAMs, activation… CONTINUE READING