Regulation of mast cell activation through FcepsilonRI.

@article{Yamasaki2005RegulationOM,
  title={Regulation of mast cell activation through FcepsilonRI.},
  author={Sho Yamasaki and Takashi K. Saito},
  journal={Chemical immunology and allergy},
  year={2005},
  volume={87},
  pages={22-31}
}
The cross-linking of FcepsilonRI on mast cells by IgE and antigen (Ag) initiates activation cascades that lead to allergic responses. FcepsilonRI is composed of an alpha and a Beta monomer, and a gamma homodimer, and the Beta and gamma chains possess immunoreceptor tyrosine-based activation motifs (ITAMs). Through the phosphorylation of ITAMs, activation… CONTINUE READING