Regulation of manganese accumulation in perinatally exposed rat pups.

  title={Regulation of manganese accumulation in perinatally exposed rat pups.},
  author={Krista Kostial and Maja Blanus̆a and Martina Piasek},
  journal={Journal of applied toxicology : JAT},
  volume={25 2},
The risk of manganese (Mn)-related ill effects in the neonate has been the topic of several investigations because in formula-fed infants Mn intake is much higher than in breast-fed infants. In the young, when Mn homeostasis is not yet developed, increased Mn intake might pose a neurotoxic risk. Our work aimed at collecting new data on Mn accumulation during the perinatal period by using an experimental rat model in pups whose mothers were exposed orally to Mn in drink (as manganese chloride… CONTINUE READING


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