Regulation of male fertility by CFTR and implications in male infertility.

  title={Regulation of male fertility by CFTR and implications in male infertility.},
  author={Hui Chen and Ye Chun Ruan and Wenming Xu and Jing Chen and Hsiao Chang Chan},
  journal={Human reproduction update},
  volume={18 6},
BACKGROUND The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl(-) and HCO(3)(-) conducting channel, mutations of which are known to be associated with male infertility. However, the underlying mechanisms remain elusive. METHODS Literature databases were searched for papers on the topics related to CFTR and male fertility and infertility with relevant keywords. Unpublished data from authors' laboratory were also included for analysis. RESULTS Clinical… CONTINUE READING
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