Regulation of malanin synthesis in mammalian cells: effect of gene dosage on the expression of differentiation.

@article{Davidson1972RegulationOM,
  title={Regulation of malanin synthesis in mammalian cells: effect of gene dosage on the expression of differentiation.},
  author={R. L. Davidson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1972},
  volume={69 4},
  pages={
          951-5
        }
}
Near-tetraploid (2S), pigmented, Syrian hamster cells (3460(2)) were hybridized with unpigmented mouse fibroblasts to produce hybrids that contained two pigment cell genomes and one fibroblast genome per cell (3(2)D). Half of the hybrids were pigmented and showed high activity of the enzyme dihydroxyphenylalanine oxidase; the other half of the hybrids were unpigmented and devoid of the activity of this enzyme. (In contrast, all the previously isolated hybrids containing only one pigment cell… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-3 OF 3 CITATIONS

References

Publications referenced by this paper.

Gene Dosage and Pigmentation in Hybrid

J. Neff, J. Enders
  • J. Cell. Physiol
  • 1965