Regulation of macrophage functions by L-arginine

  title={Regulation of macrophage functions by L-arginine},
  author={Jorge E. Albina and Michael D. Caldwell and W. Henry and Charles Dudley Mills},
  journal={The Journal of Experimental Medicine},
  pages={1021 - 1029}
Sites of inflammation with prominent macrophage infiltration, such as wounds and certain tumors, are uniquely deficient in free arginine. The effects of arginine availability on macrophage physiology were investigated. When cultured in media containing less than 0.1 mM L-arginine, rat resident peritoneal macrophages exhibited enhanced spreading, tumor cytotoxicity, superoxide production, phagocytosis, and protein synthesis. Thus, arginine concentrations similar to those found in sites of… CONTINUE READING