Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux.

@article{Argmann2005RegulationOM,
  title={Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux.},
  author={Carmen A Argmann and Jane Y. Edwards and Cynthia G. Sawyez and Caroline H. O'Neil and Robert A Hegele and J. Geoffrey Pickering and Murray W. Huff},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 23},
  pages={22212-21}
}
The cholesterol biosynthetic pathway produces numerous signaling molecules. Oxysterols through liver X receptor (LXR) activation regulate cholesterol efflux, whereas the non-sterol mevalonate metabolite, geranylgeranyl pyrophosphate (GGPP), was recently demonstrated to inhibit ABCA1 expression directly, through antagonism of LXR and indirectly through enhanced RhoA geranylgeranylation. We used HMG-CoA reductase inhibitors (statins) to test the hypothesis that reduced synthesis of mevalonate… CONTINUE READING

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Statins Enhance Macrophage Cholesterol Efflux

  • U. Laufs, J. K. Liao
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