Regulation of macrophage activation

  title={Regulation of macrophage activation},
  author={Jian-li Ma and Taiying Chen and Jami Mandelin and A. {\vC}eponis and Norman E. Miller and Mika V J Hukkanen and Guo Fen Ma and Yrj{\"o} T. Konttinen},
  journal={Cellular and Molecular Life Sciences CMLS},
IFN-γ rapidly primes the macrophage via JAK1/2-STAT1 pathway so that it can subsequently undergo a slower classical type 1 activation upon exposure to T helper (Th)1 cytokines such as IFNγ or other activators, including tumor necrosis factor and lipopolysaccharide, e.g. in intracellular killing of phagocytosed Mycobacterium tuberculosis. If instead it is driven by Th2 cytokines interleukin (IL)-4 and IL-13, it undergoes alternate type 2 activation, which enhances endocytotic antigen uptake and… CONTINUE READING
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