Regulation of mTORC1 by the Rab and Arf GTPases.

  title={Regulation of mTORC1 by the Rab and Arf GTPases.},
  author={Li Li and Eunjung Kim and Haixin Yuan and Ken Inoki and Pankuri Goraksha-Hicks and Rachel L Schiesher and Thomas P Neufeld and Kun Liang Guan},
  journal={The Journal of biological chemistry},
  volume={285 26},
The mammalian target of rapamycin (mTOR) is a key cell growth regulator, which forms two distinct functional complexes (mTORC1 and mTORC2). mTORC1, which is directly inhibited by rapamycin, promotes cell growth by stimulating protein synthesis and inhibiting autophagy. mTORC1 is regulated by a wide range of extra- and intracellular signals, including growth factors, nutrients, and energy levels. Precise regulation of mTORC1 is important for normal cellular physiology and development, and… CONTINUE READING
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