Regulation of mRNA translation and stability by microRNAs.

@article{Fabian2010RegulationOM,
  title={Regulation of mRNA translation and stability by microRNAs.},
  author={M. Fabian and N. Sonenberg and W. Filipowicz},
  journal={Annual review of biochemistry},
  year={2010},
  volume={79},
  pages={
          351-79
        }
}
MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base-pairing to the mRNA 3'-untranslated regions to repress protein synthesis by mechanisms that are not fully understood. In this review, we describe principles of miRNA-mRNA interactions and proteins that interact with miRNAs and function in miRNA-mediated repression. We discuss the multiple, often contradictory, mechanisms… Expand

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