Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein.

@article{Muesing1987RegulationOM,
  title={Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein.},
  author={Mark A. Muesing and Douglas H. Smith and Daniel Jeffrey Capon},
  journal={Cell},
  year={1987},
  volume={48 4},
  pages={691-701}
}
HIV LTR-directed expression is markedly stimulated in trans by coexpression of a region of the HIV genome encoding a portion of the tat reading frame. Transient expression assay analysis reveals that trans-activation of LTR-directed expression results primarily from an increase in mRNA accumulation. Deletion analysis of the LTR indicates that upstream promoter and enhancer elements are dispensible for trans-activation, while sequences 3' of the RNA start site displaying strict orientation and… CONTINUE READING

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