Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B.

@article{Man2016RegulationOL,
  title={Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B.},
  author={Si Ming Man and Thirumala-Devi Kanneganti},
  journal={Autophagy},
  year={2016},
  volume={12 12},
  pages={
          2504-2505
        }
}
Cysteine cathepsins are responsible for driving proteolytic degradation within the lysosome and in the extralysosomal milieu. They also have an integral role in autophagy, antigen presentation, cellular stress signaling, metabolism and lysosome-dependent cell death. Here, we discuss our findings on the role of CTSB (cathepsin B), a member of the cysteine cathepsin family, in regulating the bioavailability of lysosomes and autophagosomes and consider how this regulatory response influences host… CONTINUE READING

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