Regulation of lymphokine (gamma-interferon) production by corticotropin.

  title={Regulation of lymphokine (gamma-interferon) production by corticotropin.},
  author={Howard M Johnson and Barbara A. Torres and Eric M. Smith and L. David Dion and Jeana E. Blalock},
  journal={Journal of immunology},
  volume={132 1},
We have shown that corticotropin (ACTH), alpha-endorphin, and enkephalins can regulate antibody responses, which suggested a role for neuropeptides in a regulatory circuit between the immune and neuroendocrine systems. ACTH and structurally related peptides were examined here for regulation of mitogen induction of the lymphokine gamma-interferon (IFN gamma) in C57BL/6 mouse spleen cell cultures. Synthetic ACTH1-39 and a porcine pituitary extract containing ACTH activity were potent suppressors… CONTINUE READING
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