Regulation of lymphocyte development by Notch signaling

  title={Regulation of lymphocyte development by Notch signaling},
  author={Kenji Tanigaki and T. Honjo},
  journal={Nature Immunology},
Notch molecules are well conserved from Drosophila melanogaster to mammals and regulate a broad spectrum of various cell lineage commitment processes. Recent studies using inhibitors, transgenic mice and conditional loss-of-function approaches have demonstrated essential roles for Notch signaling in the differentiation of thymocytes and peripheral T cells, as well as B cells. Here we highlight parallels in the developmental regulation of mammalian lymphocytes and the D. melanogaster nervous… CONTINUE READING