Regulation of lymphatic-blood vessel separation by endothelial Rac1.

  title={Regulation of lymphatic-blood vessel separation by endothelial Rac1.},
  author={Gabriela D'Amico and Dylan T. Jones and Emma Nye and Karen Sapienza and Antoine R Ramjuan and Louise E Reynolds and Stephen D Robinson and Vassiliki Kostourou and Dolores L Martinez and Deborah Aubyn and Richard Grose and Gareth J Thomas and Bradley Spencer-Dene and Daniel Zicha and D. Davies and Victor L. J. Tybulewicz and Kairbaan M Hodivala-Dilke},
  volume={136 23},
Sprouting angiogenesis and lymphatic-blood vessel segregation both involve the migration of endothelial cells, but the precise migratory molecules that govern the decision of blood vascular endothelial cells to segregate into lymphatic vasculature are unknown. Here, we deleted endothelial Rac1 in mice (Tie1-Cre(+);Rac1(fl/fl)) and revealed, unexpectedly, that whereas blood vessel morphology appeared normal, lymphatic-blood vessel separation was impaired, with corresponding edema, haemorrhage… CONTINUE READING
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