Regulation of lung injury and repair by Toll-like receptors and hyaluronan

@article{Jiang2005RegulationOL,
  title={Regulation of lung injury and repair by Toll-like receptors and hyaluronan},
  author={Dianhua Jiang and Jiurong Liang and Juan Fan and Shuang Yu and Suping Chen and Yi Luo and Glenn D. Prestwich and Marcella M. Mascarenhas and Hari G. Garg and Deborah A. Quinn and Robert J. Homer and Daniel R. Goldstein and Richard J. Bucala and Patty J. Lee and Ruslan Medzhitov and Paul W. Noble},
  journal={Nature Medicine},
  year={2005},
  volume={11},
  pages={1173-1179}
}
Mechanisms that regulate inflammation and repair after acute lung injury are incompletely understood. The extracellular matrix glycosaminoglycan hyaluronan is produced after tissue injury and impaired clearance results in unremitting inflammation. Here we report that hyaluronan degradation products require MyD88 and both Toll-like receptor (TLR)4 and TLR2 in vitro and in vivo to initiate inflammatory responses in acute lung injury. Hyaluronan fragments isolated from serum of individuals with… 

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