Regulation of lung endoderm progenitor cell behavior by miR302/367.

@article{Tian2011RegulationOL,
  title={Regulation of lung endoderm progenitor cell behavior by miR302/367.},
  author={Ying Tian and Yuzhen Zhang and Laura Hurd and Sridhar Hannenhalli and Feiyan Liu and Min Min Lu and Edward E Morrisey},
  journal={Development},
  year={2011},
  volume={138 7},
  pages={1235-45}
}
The temporal and spatial control of organ-specific endoderm progenitor development is poorly understood. miRNAs affect cell function by regulating programmatic changes in protein expression levels. We show that the miR302/367 cluster is a target of the transcription factor Gata6 in mouse lung endoderm and regulates multiple aspects of early lung endoderm progenitor development. miR302/367 is expressed at early stages of lung development, but its levels decline rapidly as development proceeds… CONTINUE READING

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