Regulation of low-threshold afferent activity may contribute to short-term habituation in Aplysia californica

  title={Regulation of low-threshold afferent activity may contribute to short-term habituation in Aplysia californica
  author={T. M. Fischer and Daniel A. Jacobson and Ashley N. Counsell and Michael A. Pelot and Kristin Demorest},
  journal={Neurobiology of Learning and Memory},
The goal of this study was to characterize the contribution of a population of low-threshold mechanoreceptors to short-term habituation of siphon-elicited reflex responses in Aplysia californica. Since the location of their somata is unknown, we refer to them as the Unidentified Low-Threshold mechanoreceptors (ULTs). The ULTs operate in parallel to the higher-threshold and well-characterized LE sensory neurons, yet little is known regarding their contribution to behavioral plasticity. Using… Expand
Network processes involved in the mediation of short-term habituation in Aplysia: contribution of intrinsic regulation of excitability and synaptic augmentation
The results suggest that activity-dependent synaptic facilitation (augmentation; AUG) expressed by the L29s acts to compensate for the decreased activity in the untrained pathway, and support a role for the L 29s in regulating network dynamics during STH training, but only at rapid training intervals. Expand
Transcriptional analysis of a whole-body form of long-term habituation in Aplysia californica.
A computer-controlled brushing apparatus is constructed to apply low-intensity tactile stimulation over the entire dorsal surface of Aplysia at regular intervals and it is found that 3 d of training produces habituation with several characteristics favorable for mechanistic investigation. Expand
Brain-wide visual habituation networks in wild type and fmr1 zebrafish
It is shown that different functional categories of loom-sensitive neurons are located in characteristic locations throughout the brain, and that both the functional properties of their networks and the resulting behavior can be modulated by stimulus saliency and timing. Expand
Comparative biology of pain: What invertebrates can tell us about how nociception works.
  • B. Burrell
  • Biology, Medicine
  • Journal of neurophysiology
  • 2017
Invertebrates provide an opportunity to study nociception in an ethologically relevant context that can provide novel insights into the nature of how injury-inducing stimuli produce persistent changes in behavior. Expand


Analysis of synaptic depression contributing to habituation of gill-withdrawal reflex in Aplysia californica.
  • J. Byrne
  • Psychology, Medicine
  • Journal of neurophysiology
  • 1982
The results indicate that the recovery of synaptic depression following a train of 10 stimuli is not constant and that there may be a slight underlying facilitatory process with short spike intervals, which is inconsistent with a classical depletion model for synaptic depression. Expand
Differential role of inhibition in habituation of two independent afferent pathways to a common motor output.
It is found that repeated tail stimuli administered in the presence of a reversible conduction block of the nerves downstream of the tail sensory neurons (SNs) completely abolished the induction of habituation, and the sensitivity of T-SWR habituation to network disinhibition is consistent with an interneuronal plasticity mechanism that is unique to the T- SWR circuit. Expand
Stimulus-response relations and stability of mechanoreceptor and motor neurons mediating defensive gill-withdrawal reflex in Aplysia.
Study of the response properties of the sensory and motor neurons of the reflex during repeated stimulation at rates that produce habituation and the stability of the motor responses is described. Expand
Contribution of individual mechanoreceptor sensory neurons to defensive gill-withdrawal reflex in Aplysia.
The results indicate that the known neural elements may quantitatively account for most of the expression of the behavior and its short-term habituation. Expand
Site Specificity of Short-Term and Long-Term Habituation in the Tail-Elicited Siphon Withdrawal Reflex of Aplysia
Using the tail-elicited siphon withdrawal reflex of Aplysia, it is found that both short-term and long-term habituation can be restricted laterally, such that habituation produced by stimulation of one side of the tail does not generalize to the other side. Expand
A Simplified Preparation for Relating Cellular Events to Behavior: Contribution of LE and Unidentified Siphon Sensory Neurons to Mediation and Habituation of the Aplysia Gill- and Siphon-Withdrawal Reflex
The results support the idea that plasticity at synapses of both LE and unidentified sensory neurons contributes to habituation and dishabituation of the reflex response in this preparation. Expand
Habituation in Aplysia: The Cheshire Cat of neurobiology
  • D. Glanzman
  • Medicine, Biology
  • Neurobiology of Learning and Memory
  • 2009
The demonstration of LTD in vitro opens up a promising new avenue for attempts to relate long-term habituation to cellular changes within the nervous system of Aplysia. Expand
Acquisition and Retention of Long-Term Habituation in Aplysia: Correlation of Behavioral and Cellular Processes
A behaviorally meaningful stimulus sequence, consisting of only 40 patterned stimuli, leads to changes in synaptic effectiveness lasting one or more days in a neural pathway involved in short-term habituation of this reflex. Expand
A Simplified Preparation for Relating Cellular Events to Behavior: Mechanisms Contributing to Habituation, Dishabituation, and Sensitization of the Aplysia Gill-Withdrawal Reflex
This preparation for studying the gill-withdrawal reflex of Aplysia is developed, in which it is relatively easy to record the activity of individual neurons during simple forms of learning, and cellular mechanisms contributing to habituation, dishabituation, and sensitization are investigated. Expand
Nonuniform expression of habituation in the activity of distinct classes of neurons in the Aplysia abdominal ganglion
The authors' experiments address the issue of how habituation is expressed in the activity of the population of neurons responding to siphon stimulation by observing global observations of neuronal response in the Aplysia abdominal ganglion using voltage-sensitive dye recording. Expand