Regulation of longevity and stress resistance by Sch9 in yeast.

@article{Fabrizio2001RegulationOL,
  title={Regulation of longevity and stress resistance by Sch9 in yeast.},
  author={Paola Fabrizio and Fab{\'i}ola Pozza and Scott D. Pletcher and Christi M. Gendron and Valter D. Longo},
  journal={Science},
  year={2001},
  volume={292 5515},
  pages={
          288-90
        }
}
The protein kinase Akt/protein kinase B (PKB) is implicated in insulin signaling in mammals and functions in a pathway that regulates longevity and stress resistance in Caenorhabditis elegans. We screened for long-lived mutants in nondividing yeast Saccharomyces cerevisiae and identified mutations in adenylate cyclase and SCH9, which is homologous to Akt/PKB, that increase resistance to oxidants and extend life-span by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and… CONTINUE READING

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