Regulation of local translation at the synapse by BDNF

@article{Santos2010RegulationOL,
  title={Regulation of local translation at the synapse by BDNF},
  author={Ana Rita Santos and Diogo Comprido and Carlos B Duarte},
  journal={Progress in Neurobiology},
  year={2010},
  volume={92},
  pages={505-516}
}
The neurotrophin brain-derived neurotrophic factor (BDNF) plays a key role in synaptic plasticity, in part due to changes in local protein synthesis. Activation of TrkB (tropomyosin-related kinase B) receptors for BDNF triggers several parallel signaling pathways, including the Ras/ERK, the phosphatidylinositol 3-kinase (PI3-K) and the phospholipase C-γ pathways. Recent studies have elucidated some of the signaling mechanisms that contribute to the regulation of translation activity by BDNF… CONTINUE READING

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