Regulation of lipoprotein lipase by Angptl4

@article{Dijk2014RegulationOL,
  title={Regulation of lipoprotein lipase by Angptl4},
  author={Wieneke Dijk and Sander Kersten},
  journal={Trends in Endocrinology \& Metabolism},
  year={2014},
  volume={25},
  pages={146-155}
}
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  • M. Hassan
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The interplay between the different ANGPTLs in a coordinated manner to regulate lipid metabolism during different nutritional states may serve as potential novel therapeutic target for reducing plasma lipoprotein and treatment of metabolic syndrome.
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Angiopoietin-like proteins 3, 4 and 8 together ensure that triglycerides from triglyceride-rich lipoproteins are adequately distributed during different physiological conditions by focusing on their impact on LPL activity and plasma triglyceride clearance during physiological conditions such as fasting, refeeding, exercise and cold exposure.
Evidences for Expression and Location of ANGPTL8 in Human Adipose Tissue
TLDR
It is demonstrated that in visceral adipose tissue, ANGPTL8 is well defined in the cytoplasm of adipocytes coexisting with perilipin-1 and its mRNA, also is present in endothelial cells.
Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes
TLDR
It is concluded that ANGPTL4 promotes loss of intracellular LPL by stimulating LPL degradation after LPL processing in the ER.
Multidimensional regulation of lipoprotein lipase: impact on biochemical and cardiovascular phenotypes1
  • R. Hegele
  • Biology
    Journal of Lipid Research
  • 2016
TLDR
The complexity of the regulation of LPL secretion and activity has become more apparent and some insights have emerged from studying natural human genetic variants, as well as classical cellular and molecular biological studies of these various proteins.
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