Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta.

@article{Hirotani2005RegulationOL,
  title={Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta.},
  author={Tomonori Hirotani and Masahiro Yamamoto and Yutaro Kumagai and Satoshi Uematsu and Ichiro Kawase and Osamu Takeuchi and Shizuo Akira},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={328 2},
  pages={383-92}
}
Macrophages recognize lipopolysaccharide (LPS) by Toll-like receptor 4 and activate inflammatory responses by inducing expression of various genes. TLR4 activates intracellular signaling pathways via TIR domain containing adaptor molecules, MyD88, and Toll/IL-1 domain containing adaptor inducing IFN-beta (TRIF). Although macrophages lacking MyD88 or TRIF showed impaired cytokine production, activation of intracellular signaling molecules still occurred in response to LPS in these cells. In the… CONTINUE READING
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