Regulation of lipolysis and ketogenesis by norepinephrine in conscious dogs.

@article{Connolly1991RegulationOL,
  title={Regulation of lipolysis and ketogenesis by norepinephrine in conscious dogs.},
  author={Cynthia C Connolly and Karl E. Steiner and Ralph Stevenson and Doss W. Neal and Phillip E. Williams and K. George M. M. Alberti and Alan D. Cherrington},
  journal={The American journal of physiology},
  year={1991},
  volume={261 4 Pt 1},
  pages={E466-72}
}
The lipolytic and ketogenic effects of norepinephrine (NE) at levels present in the circulation or the synaptic cleft during stress were examined in the overnight-fasted conscious dog. Insulin and glucagon were maintained at basal levels while NE, at a rate of either 0.04 (n = 6) or 0.32 micrograms.kg-1.min-1 (n = 5), or saline (n = 6) was infused for 3 h. NE rose from 129 +/- 17 to 442 +/- 85 pg/ml (P less than 0.05) and 100 +/- 24 to 3,244 +/- 807 pg/ml (P less than 0.05) with the low and… CONTINUE READING