Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1.

  title={Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1.},
  author={Xiaoping Zhao and Daorong Feng and Qun Wang and Arian Abdulla and Xiao-Jun Xie and Jie Zhou and Yan Lindsay Sun and Ellen S T Yang and Lu-ping Liu and Bhavapriya Vaitheesvaran and Lauren Bridges and Irwin J. Kurland and Randy Strich and Jianquan Ni and Chenguang Wang and Johan Ericsson and Jeffrey E. Pessin and Jun-Yuan Ji and Fajun Yang},
  journal={The Journal of clinical investigation},
  volume={122 7},
Altered lipid metabolism underlies several major human diseases, including obesity and type 2 diabetes. However, lipid metabolism pathophysiology remains poorly understood at the molecular level. Insulin is the primary stimulator of hepatic lipogenesis through activation of the SREBP-1c transcription factor. Here we identified cyclin-dependent kinase 8 (CDK8) and its regulatory partner cyclin C (CycC) as negative regulators of the lipogenic pathway in Drosophila, mammalian hepatocytes, and… 

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  • 2011

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