Regulation of lipid and lipoprotein metabolism by PPAR activators.

  title={Regulation of lipid and lipoprotein metabolism by PPAR activators.},
  author={Philippe P. Gervois and In{\'e}s Pineda Torra and J. C. Fruchart and Bart Staels},
  journal={Clinical chemistry and laboratory medicine},
  volume={38 1},
The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. PPARalpha, the first identified PPAR family member, is principally expressed in tissues exhibiting high rates of beta-oxidation such as liver, kidney, heart and muscle. PPARgamma, on the other hand, is expressed at high levels in adipose tissue. PPARs are activated by dietary fatty acids and eicosanoids, as well as by pharmacological drugs… CONTINUE READING