Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis.

@article{Chae2004RegulationOL,
  title={Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis.},
  author={S Chae and Ji-hye Paik and Maria Laura Allende and Richard L Proia and Timothy Hla},
  journal={Developmental biology},
  year={2004},
  volume={268 2},
  pages={441-7}
}
Angiogenesis, also known as new blood vessel formation, is regulated coordinately with other tissue differentiation events during limb development. Although vascular endothelial cell growth factor (VEGF) is important in the regulation of angiogenesis, chondrogenesis and osteogenesis during limb development, the role of other angiogenic factors is not well understood. Sphingosine 1-phosphate, a platelet-derived lipid mediator, regulates angiogenesis and vascular maturation via its action on the… CONTINUE READING

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