Regulation of lifespan by histone deacetylase

  title={Regulation of lifespan by histone deacetylase},
  author={Karen T Chang and Kyung-Tai Min},
  journal={Ageing Research Reviews},
Aging is a universal biological phenomenon in eukaryotes, but why and how we age still remain mysterious. It would be of great biological interest and practical importance if we could uncover the molecular mechanism of aging, and find a way to delay the aging process while maintaining physical and mental strengths of youth. Histone deacetylases (HDACs) such as SIR2 and RPD3 are known to be involved in the extension of lifespan in yeast and Caenorhabditis elegans. An inhibitor of HDACs… CONTINUE READING


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