Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins.

@article{Sassano2009RegulationOL,
  title={Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins.},
  author={Antonella Sassano and Marco Lo Iacono and Giovanni Antico and Alison O. Jordan and Shahab Uddin and Raffaele Adolfo Calogero and Leonidas C. Platanias},
  journal={Molecular cancer therapeutics},
  year={2009},
  volume={8 3},
  pages={615-25}
}
There is emerging evidence that, beyond their cholesterol-lowering properties, statins exhibit important antileukemic effects in vitro and in vivo, but the precise mechanisms by which they generate such responses remain to be determined. We have previously shown that statins promote differentiation of acute promyelocytic leukemia cells and enhance generation of all-trans retinoic acid (ATRA)-dependent antileukemic responses. We now provide evidence that statin-dependent leukemic cell… CONTINUE READING
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