Regulation of leucine biosynthesis in Bacillus subtilis.

  title={Regulation of leucine biosynthesis in Bacillus subtilis.},
  author={Jonathan B Ward and Stanley A. Zahler},
  journal={Journal of bacteriology},
  volume={116 2},
The biosynthesis of alpha-isopropylmalate (alphaIPM) synthetase, IPM isomerase, and betaIPM dehydrogenase in Bacillus subtilis can be derepressed in leucine auxotrophs by limiting them for leucine. The derepression of the three enzymes is apparently coordinate. A class of mutants resistant to 4-azaleucine excretes leucine and has derepressed levels of all three enzymes. The azaleucine-resistance mutations may lie in a gene (azlA) encoding a repressor. Efforts to find mutations characteristic of… CONTINUE READING

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