Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals.

  title={Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals.},
  author={David M. Mills and Giuseppina Bonizzi and Michael Karin and Robert C Rickert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 15},
NF-kappaB-inducing kinase (NIK)-mediated IKKalpha phosphorylation activates the alternative NF-kappaB pathway, which is characterized by nuclear translocation of p52:RelB heterodimers. This alternative pathway is initiated by a select few receptors, including LT-betaR, BAFF-R, and CD40. Although NIK, IKKalpha, and p52 are all critical regulators of LT-betaR signaling in stromal cells during humoral immune responses, lymphocytes require NIK, but not p52, for optimal Ig production. This disparity… CONTINUE READING

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