Regulation of kinetic properties of GluR2 AMPA receptor channels by alternative splicing.

@article{Koike2000RegulationOK,
  title={Regulation of kinetic properties of GluR2 AMPA receptor channels by alternative splicing.},
  author={Masato Koike and Shota Tsukada and Kenzo Tsuzuki and Hiroshi Kijima and Seiji Ozawa},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 6},
  pages={2166-74}
}
The four subunits of the AMPA-type glutamate receptor (GluR1-GluR4 or GluR-A-GluR-D) exist in two distinct forms, flip and flop, generated by alternative splicing of a 115 bp region. The GluR2 subunit plays a key role in determining the functional properties of the AMPA receptor channel. In this study, we examined the differences in kinetic properties between the flip and flop splice variants of the GluR2 subunit expressed in Xenopus oocytes using fast agonist application techniques. Glutamate… CONTINUE READING

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