Regulation of kinesin activity by phosphorylation of kinesin-associated proteins.

@article{McIlvain1994RegulationOK,
  title={Regulation of kinesin activity by phosphorylation of kinesin-associated proteins.},
  author={J M McIlvain and Janis K Burkhardt and Sarah F Hamm-Alvarez and Yair Argon and Michael P Sheetz},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 29},
  pages={19176-82}
}
The mechanochemical motor proteins of the kinesin and cytoplasmic dynein families play important roles in microtubule-based intracellular motility. Although movement and distribution of organelles like secretory granules, vesicles, endoplasmic reticulum, and chromosomes depend on the activity of these motor proteins, little is known about the regulation of this movement. We report here that the hyperphosphorylation of components of the kinesin complex by treatment with okadaic acid increases… CONTINUE READING

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